Anti-Phospho-Neuro D (S274) antibody

Rs. 50,211.00
SKU stj90633

General Information

Product name Anti-Phospho-Neuro D (S274) antibody
Short Description
Description Rabbit polyclonal to Phospho-Neuro D (S274).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:5000
Protein Name Anti-Phospho-Neuro D (S274) antibody
Immunogen Synthesized peptide derived from human Neuro D around the phosphorylation site of S274.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 36 kDa
Database Links
Alternative Names Phospho-Neuro D (S274)
Neurogenic differentiation factor 1 antibody
NeuroD antibody
NeuroD1 antibody
Class A basic helix-loop-helix protein 3 antibody
bHLHa3 antibody
BHLHA3 antibody
NEUROD antibody
Function Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis .
Cellular Localization Cytoplasm Nucleus. In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation . Colocalizes with NR0B2 in the nucleus.
Tissue Specificity
Swiss-Prot Key

 

You recently viewed

Clear recently viewed