Anti-Phospho-NMDAε2 (S1303) antibody

Rs. 50,211.00
SKU stj90653

General Information

Product name Anti-Phospho-NMDAε2 (S1303) antibody
Short Description
Description Rabbit polyclonal to Phospho-NMDAε2 (S1303).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:40000
Protein Name Anti-Phospho-NMDAε2 (S1303) antibody
Immunogen Synthesized peptide derived from human NMDAε2 around the phosphorylation site of S1303.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 170 kDa
Database Links
Alternative Names Phospho-NMDAe2 (S1303)
Glutamate receptor ionotropic, NMDA 2B antibody
GluN2B antibody
Glutamate antibody
NMDA receptor subunit epsilon-2 antibody
N-methyl D-aspartate receptor subtype 2B antibody
NMDAR2B antibody
NR2B antibody
N-methyl-D-aspartate receptor subunit 3 antibody
NR3 antibody
hNR3 antibody
NMDAR2B antibody
Function NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death .
Cellular Localization Cell membrane. Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Multi-pass membrane protein.
Tissue Specificity Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
Swiss-Prot Key

 

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