Anti-Phospho-p107 (T369) antibody

Rs. 50,211.00
SKU stj91140

General Information

Product name Anti-Phospho-p107 (T369) antibody
Short Description
Description Rabbit polyclonal to Phospho-p107 (T369).
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Phospho-p107 (T369) antibody
Immunogen Synthesized peptide derived from human p107 around the phosphorylation site of T369.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 120.847 kDa
Database Links
Alternative Names Phospho-p107 (T369)
Retinoblastoma-like protein 1 antibody
107 kDa retinoblastoma-associated protein antibody
p107 antibody
pRb1 antibody
Function Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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