Anti-Phospho-p68 RNA Helicase (Y593) antibody

Rs. 50,211.00
SKU stj91304

General Information

Product name Anti-Phospho-p68 RNA Helicase (Y593) antibody
Short Description
Description Rabbit polyclonal to Phospho-p68 RNA Helicase (Y593).
Applications IHC,IF,ELISA
Dilution range IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000
Protein Name Anti-Phospho-p68 RNA Helicase (Y593) antibody
Immunogen Synthesized peptide derived from human p68 RNA Helicase around the phosphorylation site of Y593.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 70 kDa
Database Links
Alternative Names Phospho-p68 RNA Helicase (Y593)
Probable ATP-dependent RNA helicase DDX5 antibody
DEAD box protein 5 antibody
RNA helicase p68 antibody
G17P1 antibody
HELR antibody
HLR1 antibody
Function Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
Cellular Localization Nucleus, nucleolus
Tissue Specificity
Swiss-Prot Key

 

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