Anti-Phospho-Pdcd-4 (S67) antibody

Rs. 50,211.00
SKU stj90547

General Information

Product name Anti-Phospho-Pdcd-4 (S67) antibody
Short Description
Description Rabbit polyclonal to Phospho-Pdcd-4 (S67).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000
Protein Name Anti-Phospho-Pdcd-4 (S67) antibody
Immunogen Synthesized peptide derived from human Pdcd-4 around the phosphorylation site of S67.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat,Monkey
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 56 kDa
Database Links
Alternative Names Phospho-Pdcd-4 (S67)
Programmed cell death protein 4 antibody
Neoplastic transformation inhibitor protein antibody
Nuclear antigen H731-like antibody
Protein 197/15a antibody
H731 antibody
Function Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA .
Cellular Localization Nucleus Cytoplasm. Shuttles between the nucleus and cytoplasm . Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 .
Tissue Specificity Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.
Swiss-Prot Key

 

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