Anti-Phospho-PDGFRA-(Y849) Antibody

Rs. 50,211.00
SKU stj29335

General Information

Product name Anti-Phospho-PDGFRA-(Y849) Antibody
Short Description Rabbit Polyclonal to PhosphoPDGFRA(Y849)
Description This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-PDGFRA-(Y849) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding Y849 of human PDGFRA
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 122.7 kDa
Database Links
Alternative Names PDGFRAPlatelet-derived growth factor receptor alpha antibodyPDGF-R-alpha antibodyPDGFR-alphaPDGFRA antibodyPDGFR2 antibodyRHEPDGFRA
Function Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis, Depending on the context, promotes or inhibits cell proliferation and cell migration, Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells, Required for normal skeleton development and cephalic closure during embryonic development, Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi, Plays a role in cell migration and chemotaxis in wound healing, Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation, Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades
Cellular Localization Cell membrane.
Tissue Specificity Detected in platelets (at protein level), widely expressed, detected in brain, fibroblasts, smooth muscle, heart, and embryo, expressed in primary and metastatic colon tumors and in normal colon tissue.
Swiss-Prot Key

 

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