Anti-Phospho-PI 3-kinase p85/p55 (Y467/199) antibody

Rs. 50,211.00
SKU stj90384

General Information

Product name Anti-Phospho-PI 3-kinase p85/p55 (Y467/199) antibody
Short Description Rabbit polyclonal to Phospho-PI 3-kinase p85/p55 (Y467/199).
Description PI 3-kinase p85/p55 is a protein encoded by the PIK3R1 gene which is approximately 83,5 kDa. PI 3-kinase p85/p55 is localised to the cytoplasm, nucleus and cis-Golgi network. It is involved in RET signalling, IL-2 pathway, downstream signalling of activated FGFR2, regulation of lipid metabolism and insulin signalling-generic cascades. PI 3-Kinases are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival. PI 3-kinase p85/p55 is expressed in the nervous system, muscle, liver, heart and kidney. Mutations in the PIK3R1 gene may result in Agammaglobulinemia and SHORT syndrome. stj90384 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous PI 3-kinase p85/p55 protein which only binds about Y467/199 when Y467/199 is phosphorylated.
Applications WB,IHC,IF,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000
Protein Name Anti-Phospho-PI 3-kinase p85/p55 (Y467/199) antibody
Immunogen Synthesized peptide derived from human PI 3-kinase p85/p55 around the phosphorylation site of Y467/199.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat,Monkey
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 54/83 kDa
Database Links
Alternative Names Phospho-PI 3-kinase p85/p55 (Y467/199)
Phosphatidylinositol 3-kinase regulatory subunit alpha antibody
PI3-kinase regulatory subunit alpha antibody
PI3K regulatory subunit alpha antibody
PtdIns-3-kinase regulatory subunit alpha antibody
Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha antibody
PI3-kinase subunit p85-alpha antibody
PtdIns-3-kinase regulatory subunit p85-alpha antibody
GRB1 antibody
Function Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling . Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement .
Cellular Localization
Tissue Specificity Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
Swiss-Prot Key

 

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