Anti-Phospho-PLB (S16/T17) antibody

Rs. 50,211.00
SKU stj91324

General Information

Product name Anti-Phospho-PLB (S16/T17) antibody
Short Description
Description Rabbit polyclonal to Phospho-PLB (S16/T17).
Applications IF,ELISA
Dilution range IF 1:200-1:1000ELISA 1:10000
Protein Name Anti-Phospho-PLB (S16/T17) antibody
Immunogen Synthesized peptide derived from human PLB around the phosphorylation site of S16/T17.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 6.109 kDa
Database Links
Alternative Names Phospho-PLB (S16/T17)
Cardiac phospholamban antibody
PLB antibody
PLB antibody
Function Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
Cellular Localization Endoplasmic reticulum membrane Sarcoplasmic reticulum membrane Mitochondrion membrane Membrane. Colocalizes with HAX1 at the endoplasmic reticulum . Colocalizes with DMPK a the sarcoplasmic reticulum .
Tissue Specificity Heart muscle (at protein level).
Swiss-Prot Key

 

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