Anti-Phospho-PR (S294) antibody

Rs. 50,211.00
SKU stj90691

General Information

Product name Anti-Phospho-PR (S294) antibody
Short Description
Description Rabbit polyclonal to Phospho-PR (S294).
Applications WB,IF,ELISA
Dilution range WB 1:500-1:2000IF 1:200-1:1000ELISA 1:5000
Protein Name Anti-Phospho-PR (S294) antibody
Immunogen Synthesized peptide derived from human PR around the phosphorylation site of S294.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 98 kDa
Database Links
Alternative Names Phospho-PR (S294)
Progesterone receptor antibody
PR antibody
Nuclear receptor subfamily 3 group C member 3 antibody
NR3C3 antibody
Function The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. Isoform A: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Cellular Localization Nucleus. Cytoplasm. Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.. Isoform A: Nucleus. Cytoplasm. Mainly nuclear.. Isoform 4: Mitochondrion outer membrane
Tissue Specificity In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli.
Swiss-Prot Key

 

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