Anti-Phospho-PRKAA1-(S487) Antibody

Rs. 50,211.00
SKU stj29769

General Information

Product name Anti-Phospho-PRKAA1-(S487) Antibody
Short Description Rabbit Polyclonal to PhosphoPRKAA1(S487)
Description The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:1000
IHC 1:50 - 1:100
IF 1:50 - 1:100
Protein Name Anti-Phospho-PRKAA1-(S487) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding S487 of human PRKAA1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 64 kDa
Database Links
Alternative Names PRKAA15'-AMP-activated protein kinase catalytic subunit alpha-1 antibodyAMPK subunit alpha-1PRKAA1 antibodyAMPK1
Function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism, In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation, AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators, Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton
Cellular Localization Cytoplasm.
Tissue Specificity
Swiss-Prot Key

 

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