Anti-Phospho-PRKAB1-(S108) Antibody

Rs. 50,211.00
SKU stj29363

General Information

Product name Anti-Phospho-PRKAB1-(S108) Antibody
Short Description Rabbit Polyclonal to PhosphoPRKAB1(S108)
Description The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-PRKAB1-(S108) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding S108 of human AMPKβ1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 30.4 kDa
Database Links
Alternative Names PRKAB15'-AMP-activated protein kinase subunit beta-1 antibodyAMPK subunit beta-1 antibodyAMPKbPRKAB1 antibodyAMPK
Function Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism, In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation, AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators, Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton
Cellular Localization
Tissue Specificity
Swiss-Prot Key

 

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