Anti-Phospho-PRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ-(T514) Antibody

Rs. 50,211.00
SKU stj29379

General Information

Product name Anti-Phospho-PRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ-(T514) Antibody
Short Description Rabbit Polyclonal to PhosphoPRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ(T514)
Description
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-PRKCA/PRKCB/PRKCD/PRKCE/PRKCG/PRKCH/PRKCQ-(T514) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding T514 of human PKC (pan) (gamma)
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 76.8 kDa
Database Links
Alternative Names PRKCAProtein kinase C alpha type antibodyPKC-A antibodyPKC-alphaPRKCA antibodyPKCA antibodyPRKACA
Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP, Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle, Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells, In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B, Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2, During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development, After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion, Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility, During chemokine-induced CD4(+) T cell migration, phosphorylates CDC42-guanine exchange factor DOCK8 resulting in its dissociation from LRCH1 and the activation of GTPase CDC42 , phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation, Phosphorylates KIT, leading to inhibition of KIT activity, Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.
Cellular Localization Cytoplasm
Tissue Specificity
Swiss-Prot Key

 

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