Anti-Phospho-PTK2-(Y925) Antibody

Rs. 50,211.00
SKU stj29365

General Information

Product name Anti-Phospho-PTK2-(Y925) Antibody
Short Description Rabbit Polyclonal to PhosphoPTK2(Y925)
Description This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-PTK2-(Y925) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding Y925 of human PTK2
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 119.2 kDa
Database Links
Alternative Names PTK2Focal adhesion kinase 1 antibodyFADK 1PTK2 antibodyFAK antibodyFAK1
Function Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis, Required for early embryonic development and placenta development, Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development, Regulates axon growth and neuronal cell migration, axon branching and synapse formation
Cellular Localization Cell junction, focal adhesion, Cell membrane
Tissue Specificity Detected in b and t-lymphocytes, isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level), ubiquitous.
Swiss-Prot Key

 

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