Anti-Phospho-RELA-(S536) Antibody

Rs. 50,211.00
SKU stj28018

General Information

Product name Anti-Phospho-RELA-(S536) Antibody
Short Description Rabbit Polyclonal to PhosphoRELA(S536)
Description NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-Phospho-RELA-(S536) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding S536 of human RELA
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 60.2 kDa
Database Links
Alternative Names RELATranscription factor p65 antibodyNuclear factor NF-kappa-B p65 subunit antibodyNuclear factor of kappa light polypeptide gene enhancer in B-cells 3RELA antibodyNFKB3
Function NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis, NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one, The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity, Different dimer combinations act as transcriptional activators or repressors, respectively, NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors, NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family, In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus, NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators, The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression, The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65, p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex, Associates with chromatin at the NF-kappa-B promoter region via association with DDX1, Essential for cytokine gene expression in T-cells.
Cellular Localization Nucleus, Cytoplasm.
Tissue Specificity
Swiss-Prot Key

 

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