Anti-Phospho-Ret (Y905) antibody

Rs. 50,211.00
SKU stj91308

General Information

Product name Anti-Phospho-Ret (Y905) antibody
Short Description
Description Rabbit polyclonal to Phospho-Ret (Y905).
Applications IHC,IF,ELISA
Dilution range IHC 1:100-1:300IF 1:200-1:1000ELISA 1:5000
Protein Name Anti-Phospho-Ret (Y905) antibody
Immunogen Synthesized peptide derived from human Ret around the phosphorylation site of Y905.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 170/175 kDa
Database Links
Alternative Names Phospho-Ret (Y905)
Proto-oncogene tyrosine-protein kinase receptor Ret antibody
Cadherin family member 12 antibody
Proto-oncogene c-Ret antibody
Soluble RET kinase fragment antibody
Extracellular cell-membrane anchored RET cadherin 120 kDa fragment antibody
CDHF12 antibody
CDHR16 antibody
PTC antibody51 antibody
Function Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
Cellular Localization Cell membrane Endosome membrane
Tissue Specificity
Swiss-Prot Key

 

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