Anti-Phospho-RPA p32 (S33) antibody

Rs. 50,211.00
SKU stj90636

General Information

Product name Anti-Phospho-RPA p32 (S33) antibody
Short Description
Description Rabbit polyclonal to Phospho-RPA p32 (S33).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-Phospho-RPA p32 (S33) antibody
Immunogen Synthesized peptide derived from human RPA p32 around the phosphorylation site of S33.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 32 kDa
Database Links
Alternative Names Phospho-RPA p32 (S33)
Replication protein A 32 kDa subunit antibody
RP-A p32 antibody
Replication factor A protein 2 antibody
RF-A protein 2 antibody
Replication protein A 34 kDa subunit antibody
RP-A p34 antibody
REPA2 antibody
RPA32 antibody
RPA34 antibody
Function As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Cellular Localization Nucleus Nucleus, PML body. Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Tissue Specificity
Swiss-Prot Key

 

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