Anti-Phospho-Shb (Y246) antibody

Rs. 50,211.00
SKU stj90405

General Information

Product name Anti-Phospho-Shb (Y246) antibody
Short Description
Description Rabbit polyclonal to Phospho-Shb (Y246).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:10000
Protein Name Anti-Phospho-Shb (Y246) antibody
Immunogen Synthesized peptide derived from human Shb around the phosphorylation site of Y246.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 55 kDa
Database Links
Alternative Names Phospho-Shb (Y246)
SH2 domain-containing adapter protein B antibody
Function Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Cellular Localization Cytoplasm. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Associates with membrane lipid rafts upon TCR stimulation.
Tissue Specificity Widely expressed.
Swiss-Prot Key

 

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