Anti-Phospho-Shc (Y349) antibody

Rs. 50,211.00
SKU stj90738

General Information

Product name Anti-Phospho-Shc (Y349) antibody
Short Description
Description Rabbit polyclonal to Phospho-Shc (Y349).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000
Protein Name Anti-Phospho-Shc (Y349) antibody
Immunogen Synthesized peptide derived from human Shc around the phosphorylation site of Y349.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 62 kDa
Database Links
Alternative Names Phospho-Shc (Y349)
SHC-transforming protein 1 antibody
SHC-transforming protein 3 antibody
SHC-transforming protein A antibody
Src homology 2 domain-containing-transforming protein C1 antibody
SH2 domain protein C1 antibody
SHC antibody
SHCA antibody
Function Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span . Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Cellular Localization Cytoplasm.. Isoform p46Shc: Mitochondrion matrix. Localized to the mitochondria matrix. Targeting of isoform p46Shc to mitochondria is mediated by its first 32 amino acids, which behave as a bona fide mitochondrial targeting sequence. Isoform p52Shc and isoform p66Shc, that contain the same sequence but more internally located, display a different subcellular localization.. Isoform p66Shc: Mitochondrion. In case of oxidative conditions, phosphorylation at 'Ser-36' of isoform p66Shc, leads to mitochondrial accumulation.
Tissue Specificity Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed