Anti-Phospho-Smad2 (S465) antibody

Rs. 50,211.00
SKU stj91000

General Information

Product name Anti-Phospho-Smad2 (S465) antibody
Short Description
Description Rabbit polyclonal to Phospho-Smad2 (S465).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000
Protein Name Anti-Phospho-Smad2 (S465) antibody
Immunogen Synthesized peptide derived from human Smad2 around the phosphorylation site of S465.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 52 kDa
Database Links
Alternative Names Phospho-Smad2 (S465)
Mothers against decapentaplegic homolog 2 antibody
MAD homolog 2 antibody
Mothers against DPP homolog 2 antibody
JV18-1 antibody
Mad-related protein 2 antibody
hMAD-2 antibody
SMAD family member 2 antibody
SMAD 2 antibody
Smad2 antibody
hSMAD2 antibody
MADH2 antibody
MADR2 antibody
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Cellular Localization Cytoplasm Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 . On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 .
Tissue Specificity Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Swiss-Prot Key

 

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