Anti-Phospho-Stat2 (Y690) antibody

Rs. 50,211.00
SKU stj90772

General Information

Product name Anti-Phospho-Stat2 (Y690) antibody
Short Description
Description Rabbit polyclonal to Phospho-Stat2 (Y690).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-Phospho-Stat2 (Y690) antibody
Immunogen Synthesized peptide derived from human Stat2 around the phosphorylation site of Y690.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 113 kDa
Database Links
Alternative Names Phospho-Stat2 (Y690)
Signal transducer and activator of transcription 2 antibody
p113 antibody
Function Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state . Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively .
Cellular Localization Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
Tissue Specificity
Swiss-Prot Key

 

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