Anti-Phospho-STAT3-(Y705) Antibody

Rs. 50,211.00
SKU stj27511

General Information

Product name Anti-Phospho-STAT3-(Y705) Antibody
Short Description Rabbit polyclonal to PhosphoSTAT3(Y705)
Description The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-Phospho-STAT3-(Y705) Antibody
Immunogen A synthetic phosphorylated peptide around Y705 of human Stat3 (NP_644805.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 88.1 kDa
Database Links
Alternative Names STAT3Signal transducer and activator of transcription 3 antibodyAcute-phase response factorSTAT3 antibodyAPRF
Function Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors.
Cellular Localization Cytoplasm, Nucleus.
Tissue Specificity Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Swiss-Prot Key

 

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