Anti-Phospho-STK11-(S334) Antibody

Rs. 50,211.00
SKU stj29367

General Information

Product name Anti-Phospho-STK11-(S334) Antibody
Short Description Rabbit Polyclonal to PhosphoSTK11(S334)
Description This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-STK11-(S334) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding S334 of human STK11
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 48.6 kDa
Database Links
Alternative Names STK11Serine/threonine-protein kinase STK11 STK11 antibodyLKB1 antibodyPJS
Function Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response, Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK, Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53, Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage, Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton, Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification, Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation, Able to phosphorylate p53/TP53
Cellular Localization Nucleus, Cytoplasm, Membrane, Mitochondrion.
Tissue Specificity Ubiquitously expressed, strongest expression in testis and fetal liver
Swiss-Prot Key

 

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