Anti-Phospho-TACE (T735) antibody

Rs. 50,211.00
SKU stj90495

General Information

Product name Anti-Phospho-TACE (T735) antibody
Short Description
Description Rabbit polyclonal to Phospho-TACE (T735).
Applications WB,IHC,ELISA
Dilution range WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000
Protein Name Anti-Phospho-TACE (T735) antibody
Immunogen Synthesized peptide derived from human TACE around the phosphorylation site of T735.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 93 kDa
Database Links
Alternative Names Phospho-TACE (T735)
Disintegrin and metalloproteinase domain-containing protein 17 antibody
ADAM 17 antibody
Snake venom-like protease antibody
TNF-alpha convertase antibody
TNF-alpha-converting enzyme antibody
CD antigen CD156b antibody
CSVP antibody
TACE antibody
Function Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
Cellular Localization Membrane. Single-pass type I membrane protein.
Tissue Specificity Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Swiss-Prot Key

 

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