Anti-Phospho-Tau (S516/199) antibody

Rs. 50,211.00
SKU stj90658

General Information

Product name Anti-Phospho-Tau (S516/199) antibody
Short Description
Description Rabbit polyclonal to Phospho-Tau (S516/199).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:40000
Protein Name Anti-Phospho-Tau (S516/199) antibody
Immunogen Synthesized peptide derived from human Tau around the phosphorylation site of S516/199.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Human,Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 74 kDa
Database Links
Alternative Names Phospho-Tau (S516/199)
Microtubule-associated protein tau antibody
Neurofibrillary tangle protein antibody
Paired helical filament-tau antibody
PHF-tau antibodyL antibody
MTBT1 antibody
TAU antibody
Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Cellular Localization Cytoplasm, cytosol Cell membrane Cytoplasm, cytoskeleton Cell projection, axon. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
Tissue Specificity Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
Swiss-Prot Key

 

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