Anti-Phospho-TIP60 (S90) antibody

Rs. 50,211.00
SKU stj91271

General Information

Product name Anti-Phospho-TIP60 (S90) antibody
Short Description
Description Rabbit polyclonal to Phospho-TIP60 (S90).
Applications IHC,ELISA
Dilution range IHC 1:100-1:300ELISA 1:5000
Protein Name Anti-Phospho-TIP60 (S90) antibody
Immunogen Synthesized peptide derived from human TIP60 around the phosphorylation site of S90.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse,Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 55 kDa
Database Links
Alternative Names Phospho-TIP60 (S90)
Histone acetyltransferase KAT5 antibody
60 kDa Tat-interactive protein antibody
Tip60 antibody
Histone acetyltransferase HTATIP antibody
HIV-1 Tat interactive protein antibody
Lysine acetyltransferase 5 antibody
cPLA antibody
2-interacting protein antibody
HTATIP antibody
TIP60 antibody
Function Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity .
Cellular Localization Nucleus Nucleus, nucleolus. Cytoplasm, perinuclear region. Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region and UV irradiation induces translocation into punctuate subnuclear structures named nuclear bodies.
Tissue Specificity
Swiss-Prot Key

 

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