Anti-Phospho-TNK2-(Y284) Antibody

Rs. 50,211.00
SKU stj29355

General Information

Product name Anti-Phospho-TNK2-(Y284) Antibody
Short Description Rabbit Polyclonal to PhosphoTNK2(Y284)
Description This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-Phospho-TNK2-(Y284) Antibody
Immunogen A phospho specific peptide corresponding to residues surrounding Y284 of human TNK2
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 114.6 kDa
Database Links
Alternative Names TNK2Activated CDC42 kinase 1 antibodyACK-1TNK2 antibodyACK1
Function Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation, Transduces extracellular signals to cytosolic and nuclear effectors, Phosphorylates AKT1, AR, MCF2, WASL and WWOX, Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin, Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes, Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1, May be involved both in adult synaptic function and plasticity and in brain development, Activates AKT1 by phosphorylating it on 'Tyr-176', Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs), Phosphorylates WWOX on 'Tyr-287', Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins, Contributes to the control of AXL receptor levels, Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR, Phosphorylates WASP.
Cellular Localization Cell membrane, Nucleus, Endosome, Cell junction, adherens junction.
Tissue Specificity The tyr-284 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i,e, normal to hyperplasia (adh), ductal carcinoma in situ (dcis), invasive ductal carcinoma (idc) and lymph node metastatic (lnmm) stages, it also shows a significant increase in expression in prostate cancers during the progressive stages.
Swiss-Prot Key

 

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