Anti-Phospho-TRF1 (S219) antibody

Rs. 50,211.00
SKU stj90560

General Information

Product name Anti-Phospho-TRF1 (S219) antibody
Short Description
Description Rabbit polyclonal to Phospho-TRF1 (S219).
Applications WB,ELISA
Dilution range WB 1:500-1:2000ELISA 1:5000
Protein Name Anti-Phospho-TRF1 (S219) antibody
Immunogen Synthesized peptide derived from human TRF1 around the phosphorylation site of S219.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity Mouse
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Target

Gene ID
Gene Symbol
Molecular Weight 55 kDa
Database Links
Alternative Names Phospho-TRF1 (S219)
Telomeric repeat-binding factor 1 antibody
NIMA-interacting protein 2 antibody
TTAGGG repeat-binding factor 1 antibody
Telomeric protein Pin2/TRF1 antibody
PIN2 antibody
TRBF1 antibody
TRF antibody
TRF1 antibody
Function Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Cellular Localization Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle.
Tissue Specificity Highly expressed and ubiquitous. Isoform Pin2 predominates.
Swiss-Prot Key

 

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