Anti-Phospho-YAP1-(S127) Antibody

Rs. 50,211.00
SKU stj29333

General Information

Product name Anti-Phospho-YAP1-(S127) Antibody
Short Description Rabbit polyclonal to PhosphoYAP1(S127)
Description This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-Phospho-YAP1-(S127) Antibody
Immunogen A synthetic phosphorylated peptide around S127 of human YAP1 (NP_001123617.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 54.5 kDa
Database Links
Alternative Names YAP1Transcriptional coactivator YAP1 antibodyYes-associated protein 1 antibodyProtein yorkie homolog antibodyYes-associated protein YAP65 homologYAP1 antibodyYAP65
Function Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
Cellular Localization Cytoplasm.
Tissue Specificity Increased expression seen in some liver and prostate cancers, isoforms lacking the transactivation domain found in striatal neurons of patients with huntington disease (at protein level).
Swiss-Prot Key

 

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