Anti-PIAS2 Antibody

Rs. 68,577.00
SKU stj72173

General Information

Product name Anti-PIAS2 Antibody
Short Description Goat polyclonal to PIAS2
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-PIAS2 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 68.2 kDa
Database Links
Alternative Names PIAS2E3 SUMO-protein ligase PIAS2 PIAS2 antibodyPIASX
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway, The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied, However, it seems to be mostly involved in gene silencing, Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity, Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation, Isoform PIAS2-alpha promotes PARK7 sumoylation, Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha, Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160',
Cellular Localization Nucleus speckle,
Tissue Specificity Mainly expressed in testis, isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs,
Swiss-Prot Key

 

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