Anti-PIAS3 Antibody

Rs. 45,619.00
SKU stj29140

General Information

Product name Anti-PIAS3 Antibody
Short Description Rabbit polyclonal to PIAS3
Description This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
Protein Name Anti-PIAS3 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 452-628 of human PIAS3 (NP_006090.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 68 kDa
Database Links
Alternative Names PIAS3E3 SUMO-protein ligase PIAS3 PIAS3
Function Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway, Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth, Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.
Cellular Localization Cytoplasm
Tissue Specificity Widely expressed.
Swiss-Prot Key

 

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