Anti-PICK1 Antibody

Rs. 45,619.00
SKU stj24986

General Information

Product name Anti-PICK1 Antibody
Short Description Rabbit polyclonal to PICK1
Description The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-PICK1 Antibody
Immunogen A synthetic peptide of human PICK1
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 46.6 kDa
Database Links
Alternative Names PICK1PRKCA-binding protein antibodyProtein interacting with C kinase 1 antibodyProtein kinase C-alpha-binding proteinPICK1 antibodyPRKCABP
Function Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence, Involved in the clustering of various receptors, possibly by acting at the receptor internalization level, Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors, May be regulated upon PRKCA activation, May regulate ASIC1/ASIC3 channel, Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex
Cellular Localization Cytoplasm, perinuclear region, Membrane
Tissue Specificity Ubiquitous
Swiss-Prot Key

 

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