Anti-PIK3CG Antibody

Rs. 45,619.00
SKU stj28771

General Information

Product name Anti-PIK3CG Antibody
Short Description Rabbit polyclonal to PIK3CG
Description Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene.
Applications IHC
Dilution range IHC 1:50 - 1:100
Protein Name Anti-PIK3CG Antibody
Immunogen Recombinant protein of human PIK3CG
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 126.5 kDa
Database Links
Alternative Names PIK3CGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform antibodyPI3-kinase subunit gamma antibodyPI3K-gamma antibodyPI3Kgamma antibodyPtdIns-3-kinase subunit gammaPIK3CG
Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology, Links G-protein coupled receptor activation to PIP3 production, Involved in immune, inflammatory and allergic responses, Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents, May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge, Controls motility of dendritic cells, Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation, Participates in T-lymphocyte migration, Regulates T-lymphocyte proliferation and cytokine production, Together with PIK3CD participates in T-lymphocyte development, Required for B-lymphocyte development and signaling, Together with PIK3CD participates in neutrophil respiratory burst, Together with PIK3CD is involved in neutrophil chemotaxis and extravasation, Together with PIK3CB promotes platelet aggregation and thrombosis, Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism, May have also a lipid kinase activity-dependent function in platelet aggregation, Involved in endothelial progenitor cell migration, Negative regulator of cardiac contractility, Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels, Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation, Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis, May also have a scaffolding role in modulating cardiac contractility, Contributes to cardiac hypertrophy under pathological stress, Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Cellular Localization Cytoplasm
Tissue Specificity Pancreas, skeletal muscle, liver and heart.
Swiss-Prot Key

 

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