Anti-PIK3R5 Antibody

Rs. 61,689.00
SKU stj26729

General Information

Product name Anti-PIK3R5 Antibody
Short Description Rabbit polyclonal to PIK3R5
Description Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-PIK3R5 Antibody
Immunogen A synthetic Peptide of human PIK3R5
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 97.3 kDa
Database Links
Alternative Names PIK3R5Phosphoinositide 3-kinase regulatory subunit 5 antibodyPI3-kinase regulatory subunit 5 antibodyPI3-kinase p101 subunit antibodyPhosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit antibodyPtdIns-3-kinase regulatory subunit antibodyProtein FOAP-2 antibodyPtdIns-3-kinase p101 antibodyp101-PI3KPIK3R5
Function Regulatory subunit of the PI3K gamma complex, Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers, Required for G protein-mediated activation of PIK3CG (By similarity).
Cellular Localization Nucleus
Tissue Specificity Ubiquitously expressed with high expression in fetal brain compared to adult brain, abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
Swiss-Prot Key

 

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