Anti-PITX3 Antibody

Rs. 68,577.00
SKU stj71431

General Information

Product name Anti-PITX3 Antibody
Short Description Goat polyclonal to PITX3
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-PITX3 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 31.8 kDa
Database Links
Alternative Names PITX3Pituitary homeobox 3 antibodyHomeobox protein PITX3 antibodyPaired-like homeodomain transcription factor 3PITX3 antibodyPTX3
Function Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development, In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons, Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons, Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state, Essential for the normal lens development and differentiation, Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins, Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity),
Cellular Localization Nucleus
Tissue Specificity Highly expressed in developing eye lens
Swiss-Prot Key

 

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