Anti-PIWIL1 Antibody

Rs. 45,619.00
SKU stj28906

General Information

Product name Anti-PIWIL1 Antibody
Short Description Rabbit polyclonal to PIWIL1
Description This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB,IF
Dilution range WB 1:500 - 1:2000
IF 1:50 - 1:200
Protein Name Anti-PIWIL1 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 390-690 of human PIWIL1 (NP_004755.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 98.6 kDa
Database Links
Alternative Names PIWIL1Piwi-like protein 1 PIWIL1 antibodyHIWI
Function Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity, Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements, Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias), Not involved in the piRNA amplification loop, also named ping-pong amplification cycle, Acts as an endoribonuclease that cleaves transposon messenger RNAs, Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation, Probable component of some RISC complex, which mediates RNA cleavage and translational silencing, Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability, Required to sequester RNF8 in the cytoplasm until late spermatogenesis
Cellular Localization Cytoplasm
Tissue Specificity Expressed in spermatocytes and spermatids, also detected in prostate cancer (at protein level), detected in most fetal and adult tissues, expressed in testes, specifically in germline cells
Swiss-Prot Key

 

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