Anti-PIWIL2 Antibody

Rs. 45,619.00
SKU stj25008

General Information

Product name Anti-PIWIL2 Antibody
Short Description Rabbit polyclonal to PIWIL2
Description
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-PIWIL2 Antibody
Immunogen A synthetic peptide of human PIWIL2
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 109.8 kDa
Database Links
Alternative Names PIWIL2Piwi-like protein 2 PIWIL2 antibodyHILI
Function Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity), Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity), Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity), During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity), PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity), Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity), Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity), Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity), When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors.
Cellular Localization Cytoplasm
Tissue Specificity Expressed in adult testis and in most tumors.
Swiss-Prot Key

 

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