Anti-PLA2R1 Antibody

Rs. 68,577.00
SKU stj71941

General Information

Product name Anti-PLA2R1 Antibody
Short Description Goat polyclonal to PLA2R1
Description
Applications ELISA, FC
Dilution range
Protein Name Anti-PLA2R1 Antibody
Immunogen Internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 168.6 kDa
Database Links
Alternative Names PLA2R1Secretory phospholipase A2 receptor antibodyPLA2-R antibodyPLA2R antibody180 kDa secretory phospholipase A2 receptor antibodyC-type lectin domain family 13 member C antibodyM-type receptorPLA2R1 antibodyCLEC13C
Function Receptor for secretory phospholipase A2 (sPLA2), Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A, Also able to bind to snake PA2-like toxins, Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2, Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells, In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion, May be involved in responses in proinflammatory cytokine productions during endotoxic shock, Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities, The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B,
Cellular Localization Cell membrane
Tissue Specificity Present in lung macrophage (at protein level), highly expressed in kidney, also expressed in pancreas, amnion, choriodecidua and placenta, isoform 2 is expressed at much lower level,
Swiss-Prot Key

 

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