Anti-PLAUR Antibody

Rs. 45,619.00
SKU stj25022

General Information

Product name Anti-PLAUR Antibody
Short Description Rabbit polyclonal to PLAUR
Description This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-PLAUR Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 23-305 of human PLAUR (NP_002650.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 37 kDa
Database Links
Alternative Names PLAURUrokinase plasminogen activator surface receptor antibodyU-PAR antibodyuPAR antibodyMonocyte activation antigen Mo3 antibodyCD antigen CD87PLAUR antibodyMO3 antibodyUPAR
Function Acts as a receptor for urokinase plasminogen activator, Plays a role in localizing and promoting plasmin formation, Mediates the proteolysis-independent signal transduction activation effects of U-PA, It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form
Cellular Localization Cell membrane.
Tissue Specificity Expressed in neurons of the rolandic area of the brain (at protein level), expressed in the brain
Swiss-Prot Key

 

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