Anti-PLK2 Antibody

Rs. 45,619.00
SKU stj29146

General Information

Product name Anti-PLK2 Antibody
Short Description Rabbit polyclonal to PLK2
Description The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:200
Protein Name Anti-PLK2 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 322-671 of human PLK2 (NP_001239155.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 78.2 kDa
Database Links
Alternative Names PLK2Serine/threonine-protein kinase PLK2 PLK2 antibodySNK
Function Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition, Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains, Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1, Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome, Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity, Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression, Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively, Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.
Cellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.
Tissue Specificity Expressed at higher level in the fetal lung, kidney, spleen and heart.
Swiss-Prot Key

 

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