Anti-PPAP2A Antibody

Rs. 45,619.00
SKU stj25067

General Information

Product name Anti-PPAP2A Antibody
Short Description Rabbit polyclonal to PLPP1
Description The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-PPAP2A Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PPAP2A (NP_003702.2).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 32.2 kDa
Database Links
Alternative Names PLPP1Phospholipid phosphatase 1 PLPP1 antibodyLPP1 antibodyPPAP2A
Function Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids, Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG), Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system, Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA, May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation, It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P), The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P, It's down-regulation may contribute to the development of colon adenocarcinoma.
Cellular Localization Cell membrane
Tissue Specificity Ubiquitously expressed with highest expression found in prostate, isoform 1 is predominant in kidney, lung, placenta and liver, isoform 2 is predominant in heart and pancreas, found to be down-regulated in colon adenocarcinomas
Swiss-Prot Key

 

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