Anti-PMEL Antibody

Rs. 68,577.00
SKU stj70950

General Information

Product name Anti-PMEL Antibody
Short Description Goat polyclonal to PMEL
Description
Applications ELISA, WB
Dilution range
Protein Name Anti-PMEL Antibody
Immunogen C Terminus
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 70.3 kDa
Database Links
Alternative Names PMELMelanocyte protein PMEL antibodyME20-M antibodyME20M antibodyMelanocyte protein Pmel 17 antibodyMelanocytes lineage-specific antigen GP100 antibodyMelanoma-associated ME20 antigen antibodyP1 antibodyP100 antibodyPremelanosome protein antibodySilver locus protein homologPMEL antibodyD12S53E antibodyPMEL17 antibodySILV
Function Plays a central role in the biogenesis of melanosomes, Involved in the maturation of melanosomes from stage I to II, The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures, Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity,
Cellular Localization Endoplasmic reticulum membrane
Tissue Specificity Preferentially expressed in melanomas, some expression was found in dysplastic nevi, not found in normal tissues nor in carcinomas, normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth
Swiss-Prot Key

 

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