Anti-PML/RARA Antibody

Rs. 45,619.00
SKU stj29663

General Information

Product name Anti-PML/RARA Antibody
Short Description Rabbit polyclonal to PML
Description
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-PML/RARA Antibody
Immunogen Recombinant protein of human PML/RARA
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 97.6 kDa
Database Links
Alternative Names PMLProtein PML antibodyPromyelocytic leukemia protein antibodyRING finger protein 71 antibodyTripartite motif-containing protein 19PML antibodyMYL antibodyPP8675 antibodyRNF71 antibodyTRIM19
Function Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms, Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions, Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation), Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function, Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM, The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus, Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA, Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway, PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration
Cellular Localization Nucleus, Nucleus, nucleoplasm, Cytoplasm, Nucleus, PML body, Early endosome membrane
Tissue Specificity
Swiss-Prot Key

 

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