Anti-POLR3K Antibody

Rs. 45,619.00
SKU stj28550

General Information

Product name Anti-POLR3K Antibody
Short Description Rabbit polyclonal to POLR3K
Description This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-POLR3K Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-108 of human POLR3K (NP_057394.3).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 12.3 kDa
Database Links
Alternative Names POLR3KDNA-directed RNA polymerase III subunit RPC10 antibodyRNA polymerase III subunit C10 antibodyDNA-directed RNA polymerase III subunit K antibodyRNA polymerase III 12.5 kDa subunit antibodyRPC12.5 antibodyRNA polymerase III subunit C11 antibodyHsC11p antibodyRPC11 antibodyhRPC11POLR3K antibodyRPC11 antibodyMy010
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates, Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs, Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, Acts as nuclear and cytosolic DNA sensor involved in innate immune response, Can sense non-self dsDNA that serves as template for transcription into dsRNA, The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Cellular Localization Nucleus, nucleolus
Tissue Specificity
Swiss-Prot Key

 

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