Anti-PPARA Antibody

Rs. 45,619.00
SKU stj25068

General Information

Product name Anti-PPARA Antibody
Short Description Rabbit polyclonal to PPARA
Description Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.
Applications WB
Dilution range WB 1:500 - 1:1000
Protein Name Anti-PPARA Antibody
Immunogen A synthetic peptide of human PPARA
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 52.2 kDa
Database Links
Alternative Names PPARAPeroxisome proliferator-activated receptor alpha antibodyPPAR-alpha antibodyNuclear receptor subfamily 1 group C member 1PPARA antibodyNR1C1 antibodyPPAR
Function Ligand-activated transcription factor, Key regulator of lipid metabolism, Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC), Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety, Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids, Regulates the peroxisomal beta-oxidation pathway of fatty acids, Functions as transcription activator for the ACOX1 and P450 genes, Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2, May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Cellular Localization Nucleus
Tissue Specificity Skeletal muscle, liver, heart and kidney.
Swiss-Prot Key

 

You recently viewed

Clear recently viewed
Print Friendly and PDF