Anti-PPP1R8 Antibody

Rs. 45,619.00
SKU stj28784

General Information

Product name Anti-PPP1R8 Antibody
Short Description Rabbit polyclonal to PPP1R8
Description This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:100
Protein Name Anti-PPP1R8 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human PPP1R8 (NP_612568.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 38.5 kDa
Database Links
Alternative Names PPP1R8Nuclear inhibitor of protein phosphatase 1 antibodyNIPP-1 antibodyProtein phosphatase 1 regulatory inhibitor subunit 8PPP1R8 antibodyARD1 antibodyNIPP1
Function Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1), It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates, May also be involved in pre-mRNA splicing, Binds DNA and might act as a transcriptional repressor, Seems to be required for cell proliferation
Cellular Localization Nucleus, Nucleus speckle, Isoform Gamma: Cytoplasm.
Tissue Specificity Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas, less abundant in kidney, the concentration and ratio between isoforms is cell-type dependent, isoform alpha (>90%) and isoform beta were found in brain, heart and kidney, isoform gamma is mainly found in b-cells and t-lymphocytes, and has been found in 293 embryonic kidney cells.
Swiss-Prot Key

 

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