Anti-PPP1R9B Antibody

Rs. 61,689.00
SKU stj25085

General Information

Product name Anti-PPP1R9B Antibody
Short Description Rabbit polyclonal to PPP1R9B
Description This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Anti-PPP1R9B Antibody
Immunogen A synthetic peptide of human PPP1R9B
Storage Instruction Store at 4℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 89.2 kDa
Database Links
Alternative Names PPP1R9BNeurabin-2 antibodyNeurabin-II antibodyProtein phosphatase 1 regulatory subunit 9B antibodySpinophilinPPP1R9B antibodyPPP1R6
Function Seems to act as a scaffold protein in multiple signaling pathways, Modulates excitatory synaptic transmission and dendritic spine morphology, Binds to actin filaments (F-actin) and shows cross-linking activity, Binds along the sides of the F-actin, May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction, Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors, Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors, May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton, Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling, May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins, Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity), Required for hepatocyte growth factor (HGF)-induced cell migration.
Cellular Localization Cytoplasm, cytoskeleton, Cytoplasm, Cell membrane, Cell projection, lamellipodium, Cell projection, filopodium, Cell projection, ruffle membrane.
Tissue Specificity
Swiss-Prot Key

 

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