Anti-PSMD10 Antibody

Rs. 45,619.00
SKU stj25185

General Information

Product name Anti-PSMD10 Antibody
Short Description Rabbit polyclonal to PSMD10
Description This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-PSMD10 Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-226 of human PSMD10 (NP_002805.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 24.4 kDa
Database Links
Alternative Names PSMD1026S proteasome non-ATPase regulatory subunit 10 antibody26S proteasome regulatory subunit p28 antibodyGankyrin antibodyp28(GANKPSMD10
Function Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC), In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module, Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation, Plays an important role in RAS-induced tumorigenesis
Cellular Localization Cytoplasm
Tissue Specificity Tends to be up-regulated in cancer cells with ras mutations, including lung cancers and adenocarconimas (at protein level).
Swiss-Prot Key

 

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