Anti-PTTG1 Antibody

Rs. 68,577.00
SKU stj73588

General Information

Product name Anti-PTTG1 Antibody
Short Description Goat polyclonal to PTTG1
Description
Applications ELISA, IHC, IF, FC
Dilution range
Protein Name Anti-PTTG1 Antibody
Immunogen internal region
Storage Instruction
Type of Usage For Research Use Only (RUO).

Product Properties

Host Goat
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Isotype
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.

Target

Gene ID
Gene Symbol
Molecular Weight 22 kDa
Database Links
Alternative Names PTTG1Securin antibodyEsp1-associated protein antibodyPituitary tumor-transforming gene 1 protein antibodyTumor-transforming protein 1 antibodyhPTTGPTTG1 antibodyEAP1 antibodyPTTG antibodyTUTR1
Function Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair, Probably acts by blocking the action of key proteins, During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes, At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1, Its function is however not limited to a blocking activity, since it is required to activate ESPL1, Negatively regulates the transcriptional activity and related apoptosis activity of TP53, The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed, May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation,
Cellular Localization Cytoplasm, Nucleus
Tissue Specificity Expressed at low level in most tissues, except in adult testis, where it is highly expressed, overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer,
Swiss-Prot Key

 

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