Anti-RAD23B Antibody

Rs. 45,619.00
SKU stj29836

General Information

Product name Anti-RAD23B Antibody
Short Description Rabbit polyclonal to RAD23B
Description The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:100 - 1:200
IF 1:50 - 1:200
Protein Name Anti-RAD23B Antibody
Immunogen A synthetic peptide corresponding to a sequence within amino acids 50-150 of human RAD23B (NP_002865.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 43.2 kDa
Database Links
Alternative Names RAD23BUV excision repair protein RAD23 homolog B antibodyHR23B antibodyhHR23B antibodyXP-C repair-complementing complex 58 kDa protein antibodyp58RAD23B
Function Multiubiquitin chain receptor involved in modulation of proteasomal degradation, Binds to polyubiquitin chains, Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome, May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome
Cellular Localization Nucleus, Cytoplasm, upon entering mitosis, relocalizes in the cytoplasm without association with chromatin
Tissue Specificity
Swiss-Prot Key

 

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