Anti-RAD9A Antibody

Rs. 45,619.00
SKU stj25283

General Information

Product name Anti-RAD9A Antibody
Short Description Rabbit polyclonal to RAD9A
Description This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Applications WB,IHC,IF
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200
Protein Name Anti-RAD9A Antibody
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 162-391 of human RAD9A (NP_004575.1).
Storage Instruction Store at -20℃. Avoid freeze / thaw cycles.
Type of Usage For Research Use Only (RUO).

Product Properties

Host Rabbit
Clonality Polyclonal
Reactivity
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Target

Gene ID
Gene Symbol
Molecular Weight 42.5 kDa
Database Links
Alternative Names RAD9ACell cycle checkpoint control protein RAD9A antibodyhRAD9RAD9A
Function Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair, The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex, Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER), The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds
Cellular Localization Nucleus
Tissue Specificity
Swiss-Prot Key

 

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